Synthesis, characterization and in vitro biocompatibility study of Au/TMC/Fe₃O₄ nanocomposites as a promising, nontoxic system for biomedical applications

• Hanieh Shirazi,
• Maryam Daneshpour,
• Soheila Kashanian and
• Kobra Omidfar

Beilstein J. Nanotechnol. 2015, 6, 1677–1689, doi:10.3762/bjnano.6.170

• various fields of application, especially the biomedical sciences and biosensors. Keywords: Au/polymer/Fe3O4 nanocomposites; Au nanoparticles; cell viability; magnetic nanoparticles; N-trimethyl chitosan; Introduction Nanotechnology is the science of the fabrication of novel materials, devices and

• first 15 min. In contrast, the absorbance value for chitosan/Fe3O4 gradually decreased after two hours of incubation. This effect was also demonstrated via other experiments and could be the result of the difference in molecular composition of chitosan and TMC. TEM images of Au/polymer/Fe3O4

• nanocomposites are shown in Figure 7a,c. The darker, spherical nanoparticles (with a mean diameter of about 20 nm for Au/TMC/Fe3O4 nanoparticles and 40 nm for Au/chitosan/Fe3O4 nanoparticles) indicate successful attachment of Au nanoparticles onto the polymer-covered Fe3O4 nanoparticles. By comparison, it can be